Best Bets For Each Top 25 CBB Matchup Tuesday Night

Written By:

Drew Gniadek

Published On:

December 2, 2025 12:08 PM

Best Bets For Each Top 25 CBB Matchup Tuesday Night
  • Duke, Kentucky enter as favorites on Tuesday night of the ACC / SEC Challenge.
  • UConn is favored by 1.5 points on the road over Kansas, who has gone 1-2 against ranked opponents.

DURHAM, N.C. – Tuesday night’s college basketball slate features three top 25 matchups, two of which mark the beginning of the ACC / SEC challenge, starting with the Florida Gators facing the Duke Blue Devils.

#15 Florida vs #4 Duke Game Odds

Team Spread Moneyline Total
Florida +8.0 (-110) +290 O 156.5 (-110)
Duke -8.0 (-110) -380 U 156.5 (-110)

Duke enters the game with a perfect 8-0 record to start the season, while the Gators have gone 6-2 so far in their championship defense.

One thing that has become abundantly clear for Florida is that they do not have the same offensive firepower that they had just a season ago, with their offensive efficiency dropping from 127.8 to 118.9 and three point percentage plummeting from 35.6% to 27.6%.

This plays right into the hands of the Blue Devils, who have been suffocating on defense, recording the third best defensive efficiency and the top overall opponent effective field goal percentage.

Duke also has the ninth most efficient offense in the country, though Florida has been a top ten team defensively, so it would be unsurprising to see a low scoring affair.

Bettors should confidently pick Duke to cover the eight point spread at legal sports betting sites, as they have won each of their games by at least nine points thus far.

#5 UConn vs #21 Kansas Game Odds

Team Spread Moneyline Total
UConn -1.5 (-115) -125 O 177.0 (-110)
Kansas +1.5 (-105) +105 U 177.0 (-110)

Fifth ranked UConn enters as 1.5 point favorites over Kansas on the road Tuesday in what should be a closely contested matchup.

There is a noticeable offensive disparity between the two, with UConn ranking seventh in offensive efficiency while the Jayhawks rank just 47th in the country.

UConn ranks top 50 in both creating turnovers as well as limiting their own. Kansas ranks 131st in turnover rate and 361st in forcing turnovers, meaning the Huskies should be able to earn some extra possessions.

The Jayhawks do rank sixth in the country in defensive efficiency, but may not have enough scoring to keep up.

All things considered, trust Dan Hurley and the pedigree of the Huskies to pull this one out on the road.

#16 UNC vs #18 Kentucky Game Odds

Team Spread Moneyline Total
UNC +5.5 (-110) +190 O 163.0 (-110)
Kentucky -5.5 (-110) -230 U 163.0 (-110)

Kentucky is a 5.5 point favorite over UNC at home tonight, coming in at 5-2. UNC is 6-1 after losing their most recent game to Michigan State by a final of 74-58.

Michigan State also defeated the Wildcats just a few weeks ago by a final score of 83-66 in Lexington.

Kentucky is more efficient than UNC from two and three point range, but has recorded the 330th free throw rate in the country, while the Tar Heels rank 43rd in free throw rate.

Both teams are top 30 in opponent free throw rate, top 20 in defensive efficiency, and neither has a significant advantage in rebounding or turnovers.

Kentucky has also gone 0-2 against ranked opponents while UNC is 1-1 against top 25 teams.

Roll with UNC to cover the 5.5 point spread at legal college basketball betting sites by living at the free throw line, even if they don’t pull off an outright win.

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Ben Fiore

Drew Gniadek

Drew is currently a student at Florida State University, originally from Massachusetts. He has a background playing basketball, including both for the high school varsity team and pool basketball with his friends. Drew is a die-hard Celtics fan and also enjoys football and baseball.