- The 2026 MLB season kicks off with the New York Yankees as -120 favorites against the San Francisco Giants on MLB Opening Night.
- There are -115 odds favoring Wednesday night’s 7.0-run total to go under behind stellar starting pitching.
- Giants starter Logan Webb has -165 odds to go over 5.5 strikeouts against New York.
SAN FRANCISCO – MLB Opening Night features the San Francisco Giants as +100 home underdogs against the New York Yankees. Wednesday night’s 7.0-run projection has -115 legal sports betting odds to go under in the first game of the 2026 MLB season.
MLB Opening Night Odds
| Team | Run line | Moneyline | Total |
|---|---|---|---|
| New York Yankees | -1.5 (+155) | -120 | O7.0 (-105) |
| San Francisco Giants | +1.5 (-180) | +100 | U7.0 (-115) |
The Giants have solid +100 odds to start 2026 1-0 after a disappointing 81-81 campaign last season. The additions of Luis Arraez and Harrison Bader give the lineup a spark, and it’s clear that legal MLB betting sites are giving San Francisco respect in this one as slight home underdogs.
While it might not be the popular pick to bet the 7.0-run total to go under on MLB Opening Night, the quality of starting pitching from Yankees’ Max Fried and Giants’ Logan Webb makes it a solid bet. Logan Webb is the key to the Giants cashing their moneyline odds and projects to clear 5.5 strikeouts in his season debut.
Back Logan Webb Over 5.5 Strikeouts (-165) Vs Yankees
Webb impressed last season with his second-highest strikeout percentage (26.2%) in his career and looked to be in mid-season form after posting 4.2 scoreless innings (5 Ks) against Team Canada in the World Baseball Classic. The Giants ace has -165 odds favoring more than 5.5 strikeouts against a swing-and-miss Yankees lineup.
Logan Webb Strikeouts Prop vs Yankees
- Over 5.5 Strikeouts -165
- Under 5.5 Strikeouts +125
The Yankees had the fifth-most strikeouts per game last season, averaging 9.05 strikeouts in 2025. They were even worse on the road, averaging 9.73 strikeouts per game away from home and 8.38 strikeouts per game at Yankee Stadium.
There’s value on Webb’s alternate California sports betting strikeout props, such as +140 odds for 7+ strikeouts and +280 odds for 8+ strikeouts. Logan Webb had seven or more strikeouts in 15 of 34 starts last season.
