- The Milwaukee Brewers have +110 odds to cover the 1.5-run line against the Chicago White Sox.
- Back Hunter Brown and the Houston Astros to also cover the 1.5-run line (+110) against the Los Angeles Angels.
- The Los Angeles Dodgers are favored (-120) to defeat the Arizona Diamondbacks by 2+ runs in a favorable pitching matchup between Yoshinobu Yamamoto and Zac Gallen.
MILWAUKEE – An MLB Opening Day parlay with the Milwaukee Brewers, Houston Astros, and Los Angeles Dodgers all to cover the run line against their respective opponents comes out to +708 at Bovada Sportsbook. The first leg of this Opening Day parlay begins at 2:10 p.m. ET in Milwaukee, where the Brewers have +110 legal sports betting odds to cover the run line against the Chicago White Sox.
White Sox vs Brewers Betting Lines
| Team | Runline | Moneyline | Total |
|---|---|---|---|
| Chicago White Sox | +1.5 (-130) | +160 | O8.0 (-115) |
| Milwaukee Brewers | -1.5 (+110) | -195 | U8.0 (-105) |
The White Sox lost 102 games last season (only the Rockies had more), and it’s unlikely they start 2026 with a win at +160 odds. There’s some intriguing young talent in the Chicago lineup, but Milwaukee counters that with young talent on the mound in Jacob Misiorowski. Behind Misiorowski and a strong bullpen, back Milwaukee to cover (+110) against Chicago on Opening Day.
Pitching Favors Astros, Dodgers To Close Opening Day Parlay
Hunter Brown and the Houston Astros have +110 Texas sports betting odds to cover the run line against the Los Angeles Angels. Jose Soriano takes the mound for LA, who posted a 4.26 ERA in 2025 compared to Brown’s 2.43 earned run average.
Angels vs Astros Betting Lines
| Team | Runline | Moneyline | Total |
|---|---|---|---|
| Los Angeles Angels | +1.5 (-130) | +156 | O8.0 (-110) |
| Houston Astros | -1.5 (+110) | -190 | U8.0 (-110) |
Hunter Brown dominated the Angels last season, surrendering just two earned runs in 11 innings pitched across two starts. Pair that dominance with the return of Yordan Alvarez to a complete lineup, and the Astros are a great wager at legal MLB betting sites to cover the spread on Opening Day.
The other Los Angeles team, the LA Dodgers, has -120 odds to cover the run line against the Arizona Diamondbacks on Thursday. Aside from a superior lineup, the Dodgers are a great bet at legal CA sportsbooks based on a huge starting pitching advantage.
Diamondbacks vs Dodgers Betting Lines
| Team | Run Line | Odds | Total |
|---|---|---|---|
| Arizona Diamondbacks | +1.5 (+100) | +205 | O8.5 (-125) |
| Los Angeles Dodgers | -1.5 (-120) | -250 | U8.5 (+105) |
Los Angeles will start World Series MVP Yoshinobu Yamamoto, while the Diamondbacks will start Zac Gallen, who posted the eighth-highest ERA in the league last season. Gallen also said he would treat his final Spring Training start as he would a regular season game, where he ultimately surrendered six runs on nine hits without recording a strikeout.
