- The American League are +112 underdogs in the MLB All-Star Game despite winning 10 of the last 12 matchups with the National League.
- Shea Langeliers has +750 odds to hit a home run against a lefty-leaning National League pitching staff.
- AL +1.5 (-190) hit in 12-consecutive games, with four of the last six All-Star Games decided by a single run.
PHILADELPHIA – The National League are considerable -134 favorites over the American League in the 2026 MLB All-Star Game. While the AL only has five teams over .500 compared to 10 for the NL, the +112 legal sports betting odds for the American League are valuable with a loaded lineup.
MLB All-Star Game Odds
| Team | Runline | Moneyline | Total |
|---|---|---|---|
| American League | +1.5 (-190) | +112 | O8.5 (-105) |
| National League | -1.5 (+145) | -134 | U8.5 (-125) |
Cristopher Sanchez gets the start for the NL, but he will have to navigate around a handful of lefty-kilers in the AL lineup. Mike Trout, Yordan Alvarez, Shea Langeliers, Junior Caminero, and Bobby Witt Jr. is a remarkable start to a lineup, making them a worthy underdog with Dylan Cease (15 consecutive scoreless innings) starting on the mound.
The American League won 10 of the last 12 All Star Games, but they’ve cashed the -190 odds on the +1.5-run line in each of those 12 games. Three of the last four and four of the last six All-Star Games were decided by a single run, making this one of the best bets at MLB betting sites with -190 odds.
Best Bet To Hit A Home Run: Shea Langeliers +750
Betting on home runs in the All-Star Game is tough because guys aren’t guaranteed 3-4 at-bats like normal games, but Shea Langeliers could leave the yard in his first appearance. He will likely get at least two at-bats against left-handed Cristopher Sanchez, who has a 9.58 ERA across his last two starts.
Langeliers is hitting .324 against lefties compared to just .229 against righties and has a ridiculous 1.017 OPS against southpaws this season (9 HR). The NL has six more lefties to bring in after Sanchez, so Langeliers is worth a shot at +750 odds.
