3 Best Home Run Bets in MLB Friday Night Betting Slate

Written By:

Zachary Kelley

Published On:

July 24, 2026 2:13 PM

3 Best Home Run Bets in MLB Friday Night Betting Slate
  • Byron Buxton has +230 odds to hit a home run against the Athletics, who are starting left-handed pitcher Jacob Lopez.
  • Home Run Derby winner Jordan Walker gets a good matchup and has +400 odds to hit a dinger.
  • Bryce Eldridge closes the slate with +390 odds to hit a home run.
  • Parlaying the three home run bets offers +7985 odds at Bovada Sportsbook.

MINNEAPOLIS – The three best dinger bets for Friday’s MLB betting slate offer nearly +8000 odds when parlayed. The first home run comes from Byron Buxton, who has +230 legal sports betting odds to leave the yard against the Athletics.

Buxton gets a great matchup against Athletics’ starter Jacob Lopez, a left-hander who has a 6.64 ERA. Buxton getting a struggling lefty at home explains the short +230 price, but this matchup is too good to pass up.

The next game of the Friday night MLB betting slate pits the St. Louis Cardinals against the Cincinnati Reds, where another powerful right-handed bat faces a struggling starter. Jordan Walker has +400 odds to hit a home run in the game and could do so early considering Reds’ starter Rhett Lowder’s recent struggles.

Lowder has a 10.50 ERA over his last four starts, and opposing batters are slashing .404/.442/.652 against them in that brutal stretch. That sets up well for Walker, who already has 22 long balls this season thanks to 100th percentile bat speed and 98th percentile average exit velocity.

Bryce Eldrige HR Completes 3-Leg Dinger Parlay For Friday

The final game of the Friday night slate also offers one of the best dinger bets. San Francisco Giants’ rookie slugger Bryce Eldridge has +390 odds to hit a home run against struggling starter Grayson Rodriguez.

Rodriguez has an alarming 8.23 ERA and allows 1.29 HR/9 and a high 38.3% fly-ball rate, a scary combination that fits Eldridge’s powerful profile well. Eldridge has eight of his 10 homers this season off right-handed pitching and should thrive against Rodriguez on Friday night.

Parlaying the three dinger bets comes with +7985 odds, potentially making for a huge profit.

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Ben Fiore

Zachary Kelley

Zach graduated from Florida State University with a degree in Writing, Editing, and Media. Zach is interested in the legalization aspect of sports betting and enjoys participating in DFS. He has a passion for sports writing and most enjoys writing about football and baseball both professional and collegiate.