- The San Francisco 49ers are 3.5-point betting favorites over the Tennessee Titans.
- The Titans come back as +160 underdogs on the moneyline.
- The total for the meeting is set at just 44.0 points with -110 odds on both sides.
NASHVILLE, Tenn. – The San Francisco 49ers and Tennessee Titans will battle on Thursday night to kick-off Week 16.
The 49ers and Titans enter the game trending in opposite directions. San Francisco has won five of their last six games while Tennessee has lost three of their last four games. Legal online sportsbooks are favoring the hotter team.
49ers vs Titans Spread Odds
- San Francisco 49ers -3.5 -110
- Tennessee Titans +3.5 -110
Despite losing Derrick Henry to injury, the Titans have not abandoned their rush-first game plan. Tennessee runs the ball on 47.84% of their total plays, second-most in the NFL but has also done so on 55.02% of their total plays over the last three games.
With Derrick Henry in the lineup, the Titans averaged 5.56 yards per play. In the six games without, that number drops to 4.5.
To put that number in perspective, the Texans rank 32nd for the season in yards per play at 4.5.
— Joe Osborne (@JTFOz) December 21, 2021
Despite the commitment to the run game, the offense has simply not been the same since losing Henry and has ultimately been the downfall of the Titans. Their poor offensive play will likely continue into Week 16 which should result in an unfavorable outcome.
Titans vs 49ers Moneyline Odds
- San Francisco 49ers -185
- Tennessee Titans +160
Those that are either afraid of the hook or just feel more comfortable sacrificing the value, may be more inclined to take San Francisco on the moneyline. The value is certainly still there and could be a nice parlay piece to start off the Week 16 slate.
Betting The Total: 44.0 Points
Those betting on the NFL may be drawn to the total in the game. The average total of a Titans game has been 46.2 points while the average San Francisco game has seen 48.1 points.
However, the aforementioned struggles of the Titans offense could lead bettors towards the UNDER.
49ers vs Titans Total Odds
- OVER 44.0 -110
- UNDER 44.0 -110
Each of the last two Tennessee games has gone UNDER the set total while only one of the 49ers’ last five games has done the same. The Titans have the third-best explosive play preventing defense in the NFL which should further help the UNDER cash in this meeting.
Nick is a sports writer and die-hard sports fan. He graduated from Penn State University with a degree in Broadcast/Journalism. In his free time, he enjoys kicking back and relaxing with a good video game.