March Madness Best Bets: #9 Creighton Vs. #8 Louisville

• Creighton has +125 odds to beat Louisville in March Madness.
• Creighton is 7-2-1 ATS as an underdog.

LEXINGTON, Ky. – Tipping off the first round of March Madness on Thursday is a Big East vs. ACC Matchup between #9 Creighton and #8 Louisville and bettors can already enjoy some value plus money odds in this one.

Legal sports betting sites are slightly in favor of Louisville to advance to the second round at a 2.5-point spread in their favor.

#9 Creighton Vs. #8 Louisville

• Moneyline: Creighton (+125) vs. Louisville (-145)
• Spread: Louisville -2.5
• Total: 145.5

Take Creighton At Plus Money Over Louisville

Bettors should be all over Creighton in this one over Louisville and with plenty behind it as well. Starting with each of their recent history playing in the NCAA Tournament, this will be Creighton’s fifth straight tournament appearance and they’ve made it out of the first round in each of their last four appearances and all as a #9 seed or lower.

Louisville, on the other hand, will be playing in their first March Madness game in over five years and under a first year head coach for the team in Pat Kelsey.

Sticking with their history in a betting capacity, Creighton is 8-4 in 12 tournament games since 2021 and 8-4 against the spread as well. Louisville has had it rough going 1-3 overall and 0-4 against the spread in their previous tournament games since 2015.

On the season, Creighton is 19-13-2 against the spread on CBB online sportsbooks with a 5.7 winning margin. In situations as an underdog on the year, they’re 7-2-1 ATS with a +2.3 cover margin. While Louisville has a respectable 20-14 ATS record, 12 of those spread losses came as a favorite this season.

News tags: basketball | CBB | College Basketball | Creighton | Creighton Blue Jays | Louisville | Louisville Cardinals | March Madness | NCAA Tournament