Padres vs Giants Betting Preview: San Diego -147 At Home

Written By:

Drew Gniadek

Published On:

August 18, 2025 10:51 AM

Rays, Giants Road Dogs Against The Red Hot Padres
  • The San Diego Padres are -147 favorites over the San Francisco Giants Monday, who they have beat in seven of nine matchups this season.
  • Giants’ starter Robbie Ray has gone 1-1 in his two starts against the Padres this season.

SAN DIEGO – The San Francisco Giants travel back to California to face their in-state rivals in the San Diego Padres Monday night at 9:40 PM EST for the final series of the season between the two.

Giants vs Padres Game Odds

Team Spread Moneyline Total
Giants +1.5 (-175) +123 O 7.5 (-110)
Padres -1.5 (+150) -147 U 7.5 (-110)

Legal sports betting sites have the Padres listed as a very slight favorite in Monday night’s matchup, giving them -147 odds to win outright with San Francisco following closely at +123.

Here is a look at some key factors that will decide the outcome of this one.

Pitching Matchup

The pitching matchup is the primary reason why the odds are so close between the two teams in this game, as San Francisco will be starting their leader in ERA and WHIP in Robbie Ray, while Nestor Cortes will take the mound for San Diego.

Ray has been one of the best pitchers in baseball this season, posting a 2.98 ERA and 1.14 WHIP while amassing 152 strikeouts, all top 20 marks in the league.

However, this will be his third time facing the Padres, which could prove to be a problem. He won his first start against San Diego, allowing two runs through seven innings pitched back in June, but did not find as much success in his second start, allowing seven hits and four runs in six innings, picking up a loss.

Cortes has not been great this year since returning from injury, posting a 5.71 ERA in four starts, but was able to help the Padres pick up a win against the Giants in his last start, allowing one run through four and two thirds innings pitched last week.

Since The All-Star Break

The post All-Star break performance for these teams could not be more drastic, as the Giants have recorded the worst record in the MLB since the break, going 8-19 in their last 27 games.

During that span, they have scored just 3.93 runs per game, the fourth lowest mark in the league.

On the other hand, the Padres have been one of the best teams in the league since the break, going 17-11, tied for the third best record in that span.

While they have ranked middle of the pack in terms of scoring, averaging 4.71 runs per game, San Diego has led the MLB in fewest runs allowed per game at 3.39.

Head To Head

They’ve already faced each other nine times this season with the Padres taking home seven victories.

What’s more important to note is that just two of those games were played in San Diego, both resulting in Padres wins.

Five of the Padres’ seven wins against the Giants this season have come by multiple runs and the outcome should be no different in this one.

Pick San Diego to cover the one and a half run spread (+150) at MLB betting sites.

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Ben Fiore

Drew Gniadek

Drew is currently a student at Florida State University, originally from Massachusetts. He has a background playing basketball, including both for the high school varsity team and pool basketball with his friends. Drew is a die-hard Celtics fan and also enjoys football and baseball.