R16 Champions League Betting Odds + Predictions for 3 Late Slate Games

Champions League betting odds for the 3 p.m. ET slate begins with Borussia Dortmund as a 1.0-goal favorite (+102) against Lille.
Arsenal has +100 odds to cover the 0.5-goal spread against PSV Eindhoven on the road.
Atlético Madrid looks to upset Real Madrid on the road with +295 moneyline odds.

DORTMUND, Germany – A loaded Round of 16 Champions League slate features three exciting games to bet on starting at 3 p.m. ET. Borussia Dortmund has -165 odds to defend home field in the first leg against Lille.

Borussia Dortmund vs Lille Betting Odds

Team	Spread	Moneyline	Total
Borussia Dortmund	-1.0 (+102)	-165	O2.5, 3 (+100)
Lille	+1.0 (-122)	+440	U2.5, 3 (-120)

Dortmund’s defensive work has been elite under new manager Niko Kovac, who’s seen four clean sheets through his first six games. That stat paired with their 9-5-1 record at home in their last 15 UEFA games sets up well for Dortmund’s -165 legal sports betting odds to win on Tuesday.

Back Eindhoven (+290) To Defend Home Turf Vs Arsenal

PSV Eindhoven haven’t lost a UEFA Champions League (UCL) home game since 2018/2019, posting five wins and four draws in their last nine games in Eindhoven. They have long +290 odds to defeat Arsenal, who have lost in the Round of 16 in seven of their last eight UCL competitions.

PSV Eindhoven vs Arsenal Betting Odds

Team	Spread	Moneyline	Total
PSV Eindhoven	+0.5 (-120)	+290	O2, 2.5 (-120)
Arsenal	-0.5 (+100)	+100	U2, 2.5 (EVEN)

The best bet from this game is PSV Eindhoven to go over their 0.5-goal projection with -185 odds. Arsenal surrendered at least one goal in 13 of their last 14 road UCL games.

Take Real Madrid ML (-115) Against Atlético In Familiar Battle

Real Madrid and Atlético Madrid drew 1-1 roughly a month ago in La Liga play, but expect a different outcome for Tuesday night’s UCL match in the Round of 16. Real Madrid just lost to Real Betis on Saturday, causing Atlético to jump them in the La Liga standings, so expect an intense match in Madrid.

Real Madrid Vs Atlético Madrid Betting Odds

Team	Spread	Moneyline	Total
Real Madrid	-0.5 (-112)	-115	O2.5, 3 (-110)
Atlético Madrid	+0.5 (-108)	+295	U2.5, 3 (-110)

Real has been the hottest team in the world when it comes to European fixtures, losing just once in their last 17 games (11W, 5D, 1L). Their -115 moneyline odds are the best bet on soccer for Tuesday with Atlético dropping three-straight away knockout games in the Champions League.

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Zachary Kelley

Zach graduated from Florida State University with a degree in Writing, Editing, and Media. Zach is interested in the legalization aspect of sports betting and enjoys participating in DFS. He has a passion for sports writing and most enjoys writing about football and baseball both professional and collegiate.