- Floyd Mayweather and Manny Pacquiao have agreed to a second fight.
- Mayweather is heavily favored to win with -175 odds.
LAS VEGAS – A massive mega fight has officially been announced between Floyd Mayweather and Manny Pacquiao for the second time in their careers.
This time, though, it will take place at the first ever boxing event inside of the Sphere in Las Vegas on September 19, 2026.
FLOYD MAYWEATHER vs. MANNY PACQUIAO
Two of the greatest icons in boxing history will meet again in the first-ever professional boxing match at Sphere in Las Vegas.
Saturday September 19
LIVE globally only on Netflix#MayPac2 pic.twitter.com/3i5FtXBzgX— Netflix (@netflix) February 23, 2026
With the bout newly announced, legal sports betting sites got to work in setting the line. The line opened with Mayweather listed as a slightly heavier favorite over Pacman across the board.
There are different odds set on different boxing betting sites for this one. On Bovada, Mayweather is a -175 favorite ($100 to win $57) while at BetOnline, he’s listed at -275 ($100 to win $36).
Floyd Mayweather Vs. Manny Pacquiao Odds At Bovada
- Floyd Mayweather -175
- Manny Pacquiao +135
Floyd Mayweather Vs. Manny Pacquiao Odds At BetOnline
- Floyd Mayweather -275
- Manny Pacquiao +206
Can Mayweather Remain Perfect?
“Money” is ending his nine year retirement run to face arguably his biggest rival in Pacman and put his perfect 50–0 record on the line. The last time Mayweather fought was back in 2017, when he defeated Conor McGregor.
Pacquiao, on the other hand, has been active as of late, with his most recent bout coming in July 2025 in a draw against Mario Barrios. His last win, though, came in 2019 against Keith Thurman.
It’ll be over 11 years since Mayweather and Pacquiao last fought, come September. Mayweather won their first bout by unanimous decision with the judges’ scorecards reading 118–110, 116–112, and 116–112. Mayweather landed 34% of his punches while Pacquiao had an off night at just 19%.
