Best Bets For TNF Week 3: Miami Dolphins Vs. Buffalo Bills

Written By:

Sam Profeta

Published On:

September 17, 2025 10:29 AM

Best Bets For TNF Week 3: Miami Dolphins Vs. Buffalo Bills - James Cook
  • There are +300 odds for James Cook to score 2+ touchdowns.
  • The Miami Dolphins team total for points is set at 19.5.

BUFFALO, N.Y. – A lopsided AFC East matchup is set to kick off Week 3 of the NFL season between the Miami Dolphins and Buffalo Bills, with a league-leading 13-point opening spread set in favor of the Bills.

While this spread on legal sports betting sites could be seen as intimidating, there is plenty of value elsewhere on the odds board for this one. Those include odds on Bills RB James Cook, as well as Miami’s team total for points.

James Cook Continues Dominating Touchdowns

James Cook To Score 2+ Touchdowns

  • Yes +300

This is an absolute slam here on Cook’s odds at NFL betting sites to find paydirt at least twice in this one. The Bills’ offense has heavily leaned on him early on this season, and he’s already notched three rushing touchdowns thus far. That includes a two-touchdown outing against the New York Jets in Week 2, where the game’s script was heavily on their side, having won the game 30-10.

It should be a similar outcome on Thursday Night Football in Week 3 as the Dolphins might have the worst defense in the NFL to start the year. Miami has allowed three rushing touchdowns this season, including two in their loss to the New England Patriots last week.

With a mixture of an extremely positive game script and the lack of competitiveness from the Dolphins run defense, Cook should score multiple touchdowns in this one, and they could come early.

Dolphins Show No Signs Of Life Vs. Buffalo

Miami Dolphins Team Total Points

  • Over 19.5 +100
  • Under 19.5 -130

This could easily go down as one of the worst Miami Dolphins seasons in recent history, with how they’ve looked thus far. Miami is averaging just 17.5 points through their first two games this season. They were held to just eight points in Week 1 and scored 27 in Week 2.

While their offense did look productive in their 27-point outing in Week 2, it came against a New England Patriots defense that has allowed 23.5 points through their two games, as well as the eighth most total offensive yards to opponents at 373.

This Buffalo defense will be their toughest test yet. They are coming off of a strong 30-10 victory over another AFC East opponent, the New York Jets, in Week 2, where they also allowed just 183 total yards.

Taking a look back at their previous meetings, Buffalo has also held Miami to under three touchdowns in three of their last four meetings.

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Ben Fiore

Sam Profeta

Samuel has been writing professionally for 4 years. He comes from a sports writing background where he enjoys writing mostly about basketball and football both professional and collegiate. He is a recent graduate of Florida State University where he majored in Editing, Writing and Media with a minor in Communications. During his free time, you can find him watching or playing sports as well as playing videogames and listening to music.