- The Patriots are slight underdogs at home against the Bills, who they beat on the road in Week 5.
- The Lions are 3-3 on the road and each of their three losses came by at least seven points. They are 5.5 point underdogs against the Rams this week.
FOXBOROUGH, Mass. – Week 15 of the NFL season is right around the corner and will have huge playoff implications, perhaps none bigger than the game between the Buffalo Bills and the New England Patriots on Sunday.
In the NFC, the Los Angeles Rams will host the Detroit Lions as both teams fight for positioning in a crowded playoff picture.
Bills vs Patriots Game Odds
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Bills | -1.0 (-105) | -115 | O 49.5 (-110) |
| Patriots | +1.0 (-115) | -105 | U 49.5 (-110) |
Legal sports betting sites ever so slightly favor the Bills over the Patriots, giving them a -115 moneyline to the Patriots -105 odds.
Buffalo is coming off of an exhilarating 39-34 comeback victory against the Bengals, while the Patriots extended their win streak to ten games with a 33-15 win over the Giants.
New England Patriots Moneyline (-105)
The Bills have gone just 3-3 on the road this season while going 6-1 at home, their only loss coming to New England.
Ball game. The #Patriots have their first signature win of the Mike Vrabel-Drake Maye era: a 23-20 win to knockoff the undefeated Buffalo Bills.
The first game-winning drive of Maye’s career, and what a second half it was for the Pats QB. We are so back.
— Evan Lazar (@ezlazar) October 6, 2025
Both of the Patriots’ losses came at home in Week 1 and Week 3, but they’ve won their last five consecutive games at Gillette Stadium.
During their ten game win streak, the Patriots have allowed just 20 or fewer points eight times while scoring at least 23 points in each game and 30+ four times.
The Bills, on the other hand, have allowed 30+ points in three of their last five games and less than 20 just once.
Though it is difficult to bet against reigning league MVP Josh Allen, it is a whole lot easier when betting on the QB with the second best odds to win it this year, Drake Maye (+210).
Lions vs Rams Game Odds
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Lions | +5.5 (-105) | +225 | O 55.0 (-115) |
| Rams | -5.5 (-115) | -275 | U 55.0 (-105) |
The Rams and current MVP frontrunner Matthew Stafford (-170) are 5.5 point favorites against his former team at legal NFL betting sites.
Los Angeles completely dominated the Cardinals during their 45-17 victory in Week 14, avenging their loss to the Panthers the week before.
The Lions pulled off a big win at home over the Cowboys last week, improving their record to 8-5 and keeping them firmly in playoff contention.
Los Angeles Rams To Cover -5.5 (-115)
The Rams have been utterly dominant at home since losing to the 49ers in Week 5, going 4-0 while averaging 31 points per game with a 20.3 point average margin of victory.
Detroit has gone 3-3 on the road and each of their three losses on the road have come by at least seven points, two of the three by double digits. In fact, just one of the Lions’ five losses have come by less than a touchdown.
To make matters worse, the Lions’ average points per game drops by a full seven points on the road, scoring 26.3 points per game compared to 33.7 points per game at home.
The Rams own the third best scoring defense in the NFL, as well as the third best scoring defense at home.
