Russell Wilson

  • Russell Wilson is the highest-rated quarterback for Week 10 NFL action.
  • Mike Davis is priced low at $5,400.
  • Darren Waller is listed at $7,000 on DFS Sites.

LAS VEGAS—With Week 10 of the NFL season ready to get underway, fantasy football owners and GM’s should begin creating their one-day fantasy football lineups. There are plenty of underpriced and great value players to choose from.

There are a total of 11 main slate games to pick and choose players from on legal betting sites. With that being said, this is just a suggested lineup and should be switched around to the users liking.

Optimal NFL DFS Lineup Week 10

  • QB – Russell Wilson, Seahawks, $8,900
  • RB – Chase Edmunds, Cardinals, $7,100
  • RB – Mike Davis, Panthers, $5,400
  • WR – Cooper Kupp, Rams, $7,700
  • WR – Terry McLaurin, Washington, $7,000
  • WR – Robbie Anderson, Panthers, $6,400
  • TE – Darren Waller, Raiders, $7,000
  • FLEX – Duke Johnson, Texans, $5,800
  • Defense – Miami Dolphins, $4,700

Starting at the top with the quarterback slot, Russell Wilson needs absolutely no introduction as he has been on a tear this season no matter what team he is going up against. From a fantasy standpoint, Wilson has put on a clinic as he is yet to score below 20 points and has also scored 30 or more points in four of eight games.

He has a tough matchup with the Rams defense in Week 10 as they rank in the top 10 on daily fantasy football sites in defending opposing quarterbacks. Wilson has played against two other top-10 defensive teams this season in the Patriots and 49ers where he put up 34.4 points and 28.7 points.

That being said, Wilson could certainly continue his hot streak.

Running Backs

The first running back slot is filled out by Chase Edmonds of the Cardinals who has been filling in as the RB1. Edmonds had a tough go around in Week 9 as he rushed for 25 attempts for 70 yards, good for 10.3 fantasy points.

As long as he is the lead back, he will continue to get a high snap count as he did in Week 9.

He has a Week 10 matchup with the Buffalo Bills who have allowed opposing running backs to score at least one touchdown in two of their last three games as well as allow them to go for over 60 yards as well. With that said. Edmonds could certainly have a bounce-back game here against Buffalo.

The second running back slot is taken by Mike Davis. Davis offers tremendous value as he will be the RB1 in Week 10 with Christian McCaffrey out in Week 10 due to a shoulder injury.

Davis has proven that he can be an elite back in the league as in the six games that he has already filled in as the RB1, four of those games have seen double-digit fantasy points. He is sure to get the opportunities he needs as well as he also rushed for over 13 rush attempts in five of those six games as well.

Davis has a huge upside here at a low cost which could be beneficial to fantasy GM’s.

Wide Receivers

The first receiver slot is filled out by Cooper Kupp who needs no introduction, especially in this matchup with the Seattle Seahawks who rank dead last when it comes to defending opposing wide receivers.

In the Seahawks last three games, they have allowed opposing WR1’s to go for 118 yards, 91 yards and a touchdown and 103 yards and a touchdown. Not to mention, Cooper Kupp is also coming off of a great game where he saw a season-high 20 targets which for 11 receptions and 110 yards.

With that said, the stars are aligning for Kupp to have another breakout game here.

The second receiver roster spot is taken by Terry McLaurin who has been red hot in his last three games. McLaurin has gone for 74 yards, 90 yards and a touchdown and 115 yards and a touchdown in his last three games.

He has an average matchup with a Lions defense that ranks 12 in the NFL against opposing wide receivers. In two of the Lions past three games, opposing wide receivers have gone for 54 yards and two touchdowns and 97 yards.

Being that McLaurin has improved in each of his last three games, he could be in store for another nice night here against the Lions.

The final receiver slot is filled out by Robby Anderson. Anderson has had a great first year with the Carolina Panthers as he has emerged as the teams WR1.

He has had a quiet last three games, however, as he has gone for 74 yards, 48 yards and 63 yards all on eight targets or more. He could see a bounce-back game here against the Tampa Bay Buccaneers who he faced earlier in the season.

In his first go-around with the Bucs, Anderson lit them up as he saw 10 targets for nine receptions, 109 yards, and a touchdown. As long as Anderson remembers what he can do against this team, he is sure to have another nice night here.

Tight End

Darren Waller takes over the tight end slot here against the Denver Broncos. Waller has been the go-to guy for Derek Carr as he has seen six or more targets in his last four games including 10 in his last outing.

Waller has been somewhat quiet so far on the season but he is coming off of a nice game where he saw five receptions for 22 yards and a touchdown.

The fact that this is a divisional game as well could light a spark under Waller as well-being that the Raiders are fighting for a playoff spot. Waller is the top-rated tight-end on fantasy football sites for a reason and can be fired up on all rosters.


Taking over the flex slot is Duke Johnson of the Houston Texans. Duke Johnson will be stepping in as the RB1 for the Texans as David Johnson went down with a concussion in Week 9 early on.

Duke stepped in and had a great outing once David Johnson went down as he saw 16 rush attempts for 41 yards, a rushing touchdown and 32 receiving yards for 13.3 fantasy points.

With that being said, Johnson will serve as a workhorse for the Texans in Week 10 and likely see double-digit fantasy points once again.


Filling out the defense on this roster is the Miami Dolphins who have been absolutely killing it this season.

In their last three games, the Dolphins defense has put up 12 or more points in three of their previous four games. Their defense has allowed the third least amount of points this season as well as the second least amount of third-down conversions.

That should be more than enough for fantasy GM’s to confidently start them.

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