Kyler Murray is expected to rack up plenty of fantasy points this week.

  • Kyler Murray is priced at $8,400 on DFS sites.
  • DeAndre Hopkins is the top-rated wide receiver on daily fantasy football sites.
  • Chase Edmonds costs $6,000 on fantasy football sites.

BUFFALO, N.Y. — With Week 6 of NFL action coming to a close, daily fantasy football GM’s have a lot to look forward to with a doubleheader for Monday Night Football featuring the Kansas City Chiefs taking on the Buffalo Bills in the early window and the Arizona Cardinals facing off with the Dallas Cowboys later on.

Legal sports betting sites allow their users to create different lineups with the players in both games. With that said, this is just a suggested lineup and should be switched around to the users liking.

QB – Kyler Murray, Cardinals, $8,400
RB – Clyde Edwards-Helaire, Chiefs, $7,400
RB – Chase Edmonds, Cardinals, $6,000
WR – DeAndre Hopkins, Cardinals, $8,800
WR – Stefon Diggs, Bills, $7,100
WR – CeeDee Lamb, Cowboys, $6,400
TE – Dalton Schultz, Cowboys, $5,200
FLEX – Devin Singletary, Bills, $6,300
Defense – Arizona Cardinals, $4,100


Starting at the top with the quarterback slot, Kyler Murray fills out the position as he has one of the more favorable matchups amongst the other QB’s. Those that have been betting on the NFL know that Murray has been on an absolute tear this season as he is the sixth-ranked quarterback in the league averaging 25.9 fantasy points per game.

He is going into Week 6 with a more than favorable matchup against the Dallas Cowboys who rank 19 in the NFL against opposing quarterbacks. Not to mention, Murray is coming off of a huge 380 passing yard game as well so he definitely has the momentum to continue wreaking havoc here against the Cowboys.

Running Backs

The first running back slot is filled out by Clyde Edwards-Helaire. Of all the running backs that are available to choose from, CEH has the most to prove out of the bunch. The reason behind it being that the Chiefs just signed Le’Veon Bell who is a huge threat to CEH in terms of rushing attempts and goal-line work.

Bell will not be making his Chiefs debut just yet which means that Edwards-Helaire will get a shot to prove himself as the RB1 on this team.

As for his matchup, the Bills are a tougher run defense as they rank 11 in the league against opposing running backs but that should not be discouraging as CEH is the clear RB1 with no threat here in Week 6 and will get the touches if the Chiefs get out to a big lead as they normally do.

Chase Edmonds of the Arizona Cardinals is the one who fills out the second running back slot. Some daily fantasy football GM’s might think that this is a risky pickup, but Edmonds will likely get great opportunities here against the Dallas Cowboys.

Edmonds is set up for a breakout game in Week 6 and he has the poor play of Kenyan Drake to thank for that as Drake, who started out as the RB1 for the Cardinals, has been awful this season as he is the ranked 35 out of the leagues running backs as he averaged 10.3 fantasy points a game.

The Cardinals also have a nice matchup with the Cowboys run defense that ranks 17 in the league.

Wide Receivers

The first wideout spot is taken by nonother than DeAndre Hopkins who is the top receiving option during MNF in Week 6. Hopkins is slated for a huge game against a horrible Cowboys secondary that ranks 31 against opposing wide receivers.

On top of the easy matchup for Hopkins, he has put up huge numbers this season as in five games he has record three with over 130 receiving yards.

He is clearly Kyler Murray’s favorite receiver and is certain to absolutely show out against the Cowboys.

Stefon Diggs fills out the second wide receiver slot and rightfully so. Diggs has had himself a season to remember thus far as he has emerged as one of the league’s top receivers on a high-powered Bills offense.

Out of five games played this season, Diggs has posted three with over 105 receiving yards. He gets the most targets in every game as well, being that he has emerged as a favorite target for Josh Allen to sling it to. He has also been the most consistent receiver out of the Bills receiving core as well which is another reason to roster him.

The final receiver slot is taken by CeeDee Lamb. This pickup could go two ways, it could either go really well as Lamb finds new chemistry with the Cowboys new QB1, Andy Dalton, or it could be a botch if the team decides to run the ball more without Dak Prescott under center.

Lamb has been a very solid receiver for the Cowboys thus far so it is hard to see him not getting the targets needed to produce big numbers.

Something else to factor in is that the Cardinals rank 4 against opposing wide receivers but this should not raise concerns as their top defensive backs will likely shadow the team WR1 Amari Cooper and the more seasoned Michael Gallup which would leave Lamb the ability to make big plays.

Tight End

The Tight end position is filled out by Dalton Schultz. Schultz is a solid option here especially for the Cowboys first game without Dak Prescott as he could serve as a security blanket for Andy Dalton to make quick and short plays.

He also serves as a great red-zone target as well and does get the targets he needs in each game to make a difference on a fantasy team.

Even though he shares the field with guys like Amari Cooper, Michael Gallup, CeeDee Lamb and even Ezekiel Elliot, he has managed to reel in five or more targets in three out of five games this season. Fantasy owners would certainly get the most value out of playing Schultz here in Week 6.


Devin Singletary takes over as the Flex option and this could turn out to be the diamond in the rough pick here. He is the RB1 for a run-heavy Bills offense and has a great matchup with a very weak Kansas City Chiefs run defense that ranks low at 23 in the league.

Singletary clearly gets the rush attempts that he needs in order to put up good numbers and during MNF his rushing attempts should pay off.

Going back to the Chiefs run defense, they have allowed big games against opposing teams RB1’s as they allowed 77 yards and two touchdowns in Week 5, 100 yards in Week 4, 83 yards in Week 3, 93 yards in Week 2 and 77 yards and a touchdown in Week 1.

These numbers should sway fantasy owners to fire up Singletary at all costs.


Of the four defenses to choose from for the MNF doubleheader, the Cardinals make the most sense to pick up as they are going up against the Cowboys offense that as a whole, ranks 20 in the league.

Also, the fact that the Cowboys no longer have Dak under center and are now leaning on Andy Dalton could take some time to get used to for the Cowboys in which the Cardinals could easily take advantage of.

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